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Inactivation and risk control of pathogenic microorganisms in municipal sludge treatment: A review

《环境科学与工程前沿（英文）》 2022年 第16卷 第6期 doi: 10.1007/s11783-021-1504-5

摘要：

• Diversity and detection methods of pathogenic microorganisms in sludge.

关键词： Sludge treatment     Pathogenic microorganisms     Inactivation mechanisms     Exposure risks     Land application    

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Long-term exposure to air pollution and cerebrovascular disease: findings from Beijing Health Management

《环境科学与工程前沿（英文）》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1684-2

摘要：

● This study explored the long-term association by double robust additive models.

关键词： Air pollution     Cerebrovascular disease     Incidence     Long-term exposure     Doubly robust additive model    

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Untargeted metabolomic analysis of pregnant women exposure to perfluorooctanoic acid at different degrees

《环境科学与工程前沿（英文）》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1628-x

摘要：

● Metabolome can distinguish pregnant women exposure to PFOA at different degrees.

关键词： Perfluorooctanoic acid     Exposure     Pregnant women     Metabolomic     GSH     Microbiota metabolism    

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Ultraviolet exposure enhanced silicon direct bonding

Guanglan LIAO, Xuekun ZHANG, Xiaohui LIN, Canghai MA, Lei NIE, Tielin SHI,

《机械工程前沿（英文）》 2010年 第5卷 第1期   页码 87-92 doi: 10.1007/s11465-009-0078-x

摘要： Ultraviolet (UV) exposure, as an additional technique following the traditional wet chemical activation processes, is applied to enhance hydrophilic silicon direct bonding. The effects of UV exposure on silicon wafers’ nano-topography and bonding strength are studied. It is found that the surface roughness of silicon wafers initially decreases and then increases with UV exposure time, and the bonding strength increases and then decreases accordingly. The correlations of annealing temperature and annealing time vs. bonding strength are experimentally explored. Results indicate that the bonding strength increases sharply then gently with increasing annealing temperature and annealing time using UV exposure. Besides, the reliability of silicon direct bonding with UV exposure enhancement after the high/low temperature cycle test, constant temperature and humidity test, vibration test and shock test is investigated. It follows from the results that the bonding strength of silicon wafer pairs with UV exposure decreases after the environmental tests, whereas the residual strength is still higher than that without UV exposure, and the variation trends of bonding strength vs. UV exposure time, annealing temperature and annealing time remain unchanged. Therefore, following the traditional wet chemical activation processes, appropriate UV exposure (about three minutes in this study) is effective and promising to enhance silicon direct bonding.

关键词： ultraviolet (UV) exposure     silicon direct bonding     bonding strength     reliability    

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Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational

《医学前沿（英文）》 2022年 第16卷 第2期   页码 176-184 doi: 10.1007/s11684-021-0885-y

摘要： Studies of human and mammalian have revealed that environmental exposure can affect paternal health conditions as well as those of the offspring. However, studies that explore the mechanisms that meditate this transmission are rare. Recently, small noncoding RNAs (sncRNAs) in sperm have seemed crucial to this transmission due to their alteration in sperm in response to environmental exposure, and the methodology of microinjection of isolated total RNA or sncRNAs or synthetically identified sncRNAs gradually lifted the veil of sncRNA regulation during intergenerational inheritance along the male line. Hence, by reviewing relevant literature, this study intends to answer the following research concepts: (1) paternal environmental factors that can be passed on to offspring and are attributed to spermatozoal sncRNAs, (2) potential role of paternal spermatozoal sncRNAs during the intergenerational inheritance process, and (3) the potential mechanism by which spermatozoal sncRNAs meditate intergenerational inheritance. In summary, increased attention highlights the hidden wonder of spermatozoal sncRNAs during intergenerational inheritance. Therefore, in the future, more studies should focus on the origin of RNA alteration, the target of RNA regulation, and how sncRNA regulation during embryonic development can be sustained even in adult offspring.

关键词： small noncoding RNAs     epigenetic inheritance     paternal intergenerational inherence     extracellular vesicles    

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Construction risks of Huaying mount tunnel and countermeasures

Haibo YAO, Feng GAO, Shigang YU, Wei DANG

《结构与土木工程前沿（英文）》 2017年 第11卷 第3期   页码 279-285 doi: 10.1007/s11709-017-0414-x

摘要： The Chongqing-Guang’an motorway is planned to cross Huaying mount at Jingguan town of Chongqing city. The whole mount is a colossal anticline whose core is consisted of coal measure strata (upper Permian Longtan formation P l) and the limbs are limestone strata (middle Triassic Leikoupo formation T l and lower Triassic Jialingjiang formation T j). The tunneling is full of risks of collapse, gas explosion or gas outburst, water (mud) inrush, gas inrush because of existence of faults, high pressure gas, karst tectonics and coal goafs around the tunnel. In order to cope with the high risk, two main countermeasures were taken to ensure security of construction. One is geology prediction, and the other is automatic wireless real-time monitoring system, which contains monitoring of video, wind speed, poisonous gas (CH , CO, H S, SO ), people location, and automatic power-off equipment while gas contents being more than warning threshold. These ascertained the engineering safety effectively.

关键词： tunnel?construction     gas?outburst     geology?prediction     automatic?monitoring?system    

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Study of blood exposure-related mental health illness among clinical nurses

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《医学前沿（英文）》 2017年 第11卷 第1期   页码 147-151 doi: 10.1007/s11684-016-0481-8

摘要：

Nurses are subjected to high amount of stress in the medical setting, and work-related stress often leads to mental problems. This study aims to investigate the mental health status of nurses exposed to blood through needlestick injuries. A total of 302 nurses working in the hospital of Guangdong, China, participated in this study. Out of the 302 nurses, 140 did not experience any needlestick injuries during the previous week, whereas 162 nurses experienced needlestick injuries. The General Health Questionnaire (GHQ)-28 Standardized Questionnaire, which uses physical, anxiety, social function, and depression subscales, was used in this study. No significant difference between nurses exposed to blood and nurses not exposed to blood was found in terms of gender, age, length of employment, and civil status (P>0.05). Results from the GHQ-28 Standardized Questionnaire showed that 75.9% (123/162) of nurses exposed to blood were suspected to suffer from mental disorders, whereas 40% (56/140) of nurses not exposed to blood were suspected to suffer from mental disorders. The mean mental health scores of nurses exposed to blood and those not exposed were 8.73±7.32 and 5.69±5.70, respectively. From these results, we can conclude that blood exposure from needlestick injuries leads to higher prevalence of depression, anxiety, and stress symptoms in nurses. This finding highlights the importance of providing efficient, adequate, and appropriate support services after nurses are exposed to blood from needlestick injuries.

关键词： blood exposure     needlestick injuries     mental health     nurses    

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New medical risks affecting obstetrics after implementation of the two-child policy in China

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《医学前沿（英文）》 2017年 第11卷 第4期   页码 570-575 doi: 10.1007/s11684-017-0552-5

摘要：

China recently instituted a two-child policy in response to its aging population, declining workforce and demographic dividend, and the need to develop asocial economy. Additionally, women generally delay having a second child because of the overwhelming pressure in their lives. With the improvements in assisted fertility technologies in recent years, the number of elderly women attempting to bear children has increased. The quality of woman’s eggs and a man’s sperm declined dramatically with increasing age, leading to an increased risk of pregnancy-related complications among older women. Therefore, the types of fertility problems experienced by elderly females must be provided with considerable attention by obstetricians. This commentary article focuses on the medical problems faced by older second-child pregnant women. This work discusses their increased rates of infertility, spontaneous abortion, fetal malformation, gestational diabetes, cesarean section, placenta previa, postpartum hemorrhage, postpartum depression, and hypertensive disorders, which complicate pregnancy.

关键词： two-child policy     birth defects     cesarean delivery     placenta previa    

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Effects of hemin and thermal stress exposure on JWA expression

ZHAO Ming, CHEN Rui, LI Aiping, ZHOU Jianwei

《医学前沿（英文）》 2007年 第1卷 第1期   页码 104-108 doi: 10.1007/s11684-007-0020-8

摘要： To investigate the expression of JWA after hemin and (or) thermal stress exposure, we treated K562 (chronic myelogenous leukemia cells) cells with different doses of hemin and thermal stress using different exposure times. The expression of JWA protein was determined by Western blot analysis. Reverse transcription-polymerase chain reaction was carried out to determine JWA mRNA expression. JWA promoter transcription activity analysis was performed by chloramphenicol acetyl transferase-enzyme linked immunosorbent assay (CAT-ELISA). The expression of JWA protein was significantly increased by up to (3.23±0.57) folds compared to the control in K562 cells after hemin treatment (50 µM for one week), and a similar pattern was observed in the cells after treatment with thermal stress (42 °C) for 2 hours [increased by (8.00±1.73) folds]. The expression of JWA mRNA was also significantly elevated by up to (1.37±0.06) folds in K562 cells treated with hemin (30 µM for 48 hours), and a similar regulatory pattern [increased by (1.87±0.13) folds] was observed with thermal stress exposure (42 °C) for 30 minutes. However, a combined antagonistic effect was observed in the treatment of K562 cells with hemin (30 µM, 48 h) followed by thermal stress (42 °C, 30 min). CAT-ELISA further confirmed that either hemin or thermal stress treatment could up-regulate JWA transcription activity, however, the effects could be counteracted partly by treatment with a combination of both. Hemin and thermal stress might regulate JWA expression via distinct intracellular signal transduction pathways.
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Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

《医学前沿（英文）》 2011年 第5卷 第4期   页码 356-371 doi: 10.1007/s11684-011-0159-1

摘要： Virus-based vectors are widely used in hematopoietic stem cell (HSC) gene therapy, and have the ability to integrate permanently into genomic DNA, thus driving long-term expression of corrective genes in all hematopoietic lineages. To date, HSC gene therapy has been successfully employed in the clinic for improving clinical outcomes in small numbers of patients with X-linked severe combined immunodeficiency (SCID-X1), adenosine deaminase deficiency (ADA-SCID), adrenoleukodystrophy (ALD), thalassemia, chronic granulomatous disease (CGD), and Wiskott-Aldrich syndrome (WAS). However, adverse events were observed during some of these HSC gene therapy clinical trials, linked to insertional activation of proto-oncogenes by integrated proviral vectors leading to clonal expansion and eventual development of leukemia. Numerous studies have been performed to understand the molecular basis of vector-mediated genotoxicity, with the aim of developing safer vectors and lower-risk gene therapy protocols. This review will summarize current information on the mechanisms of insertional mutagenesis in hematopoietic stem and progenitor cells due to integrating gene transfer vectors, discuss the available assays for predicting genotoxicity and mapping vector integration sites, and introduce newly-developed approaches for minimizing genotoxicity as a way to further move HSC gene therapy forward into broader clinical application.

关键词： gene therapy     hematopoietic stem cells     insertional mutagenesis     genotoxicity     induced pluripotent stem cell    

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Occupational risk of exposure to methicillin-resistant (MRSA) and the quality of infection hygiene in

《环境科学与工程前沿（英文）》 2021年 第15卷 第3期 doi: 10.1007/s11783-020-1333-y

摘要：

• Staff members were not colonised with MRSA.

关键词： Antibiotic resistance     Airborne MRSA     Bioaerosols     Healthcare-associated infections     Healthcare worker     Occupational health    

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Universal influenza virus vaccines: what can we learn from the human immune response following exposure

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《医学前沿（英文）》 2017年 第11卷 第4期   页码 471-479 doi: 10.1007/s11684-017-0602-z

摘要：

Several universal influenza virus vaccine candidates based on eliciting antibodies against the hemagglutinin stalk domain are in development. Typically, these vaccines induce responses that target group 1 or group 2 hemagglutinins with little to no cross-group reactivity and protection. Similarly, the majority of human anti-stalk monoclonal antibodies that have been isolated are directed against group 1 or group 2 hemagglutinins with very few that bind to hemagglutinins of both groups. Here we review what is known about the human humoral immune response to vaccination and infection with H7 subtype influenza viruses on a polyclonal and monoclonal level. It seems that unlike vaccination with H5 hemagglutinin, which induces antibody responses mostly restricted to the group 1 stalk domain, H7 exposure induces both group 2 and cross-group antibody responses. A better understanding of this phenomenon and the underlying mechanisms might help to develop future universal influenza virus vaccine candidates.

关键词： universal influenza virus vaccine     hemagglutinin stalk     H7N9    

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Response of bacterial communities to short-term pyrene exposure in red soil

Jingjing PENG, Hong LI, Jianqiang SU, Qiufang ZHANG, Junpeng RUI, Chao CAI

《环境科学与工程前沿（英文）》 2013年 第7卷 第4期   页码 559-567 doi: 10.1007/s11783-013-0501-8

摘要： Pyrene, a representative polycyclic aromatic hydrocarbon (PAH) compound produced mainly from incomplete combustion of fossil fuels, is hazardous to ecosystem health. However, long-term exposure studies did not detect any significant effects of pyrene on soil microorganism. In this study, short-term microcosm experiments were conducted to identify the immediate effect of pyrene on soil bacterial communities. A freshly-collected pristine red soil was spiked with pyrene at 0, 10, 100, 200, and 500 mg·kg and incubated for one day and seven days. The bacterial communities in the incubated soils were analyzed using 16S rRNA sequencing and terminal restriction fragment length polymorphism (T-RFLP) methods. The results revealed high bacterial diversity in both unspiked and pyrene-spiked soils. Only at the highest pyrene-spiking rate of 500 mg·kg , two minor bacteria groups of the identified 14 most abundant bacteria groups were completely suppressed. Short-term exposure to pyrene resulted in dominance of Proteobacteria in soil, followed by Acidobacteria, Firmutes, and Bacteroidetes. Our findings showed that bacterial community structure did respond to the presence of pyrene but recovered rapidly from the perturbation. The intensity of impact and the rate of recovery showed some pyrene dosage-dependent trends. Our results revealed that different levels of pyrene may affect the bacterial community structure by suppressing or selecting certain groups of bacteria. It was also found that the bacterial community was most susceptible to pyrene within one day of the chemical addition.

关键词： pyrene     bacterial communities     terminal restriction fragment length polymorphism     short-term exposure     rank-abundance plots    

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Influence of initial curing conditions and exposure environments on chloride migration in concrete using

Wen XUE, Weiliang JIN, Hiroshi YOKOTA,

《结构与土木工程前沿（英文）》 2010年 第4卷 第3期   页码 348-353 doi: 10.1007/s11709-010-0077-3

摘要： To investigate the influence of initial curing conditions and exposure environments on chloride ions’ migration in concrete, the specimens that were cured in different conditions and placed in several marine environments were studied. The amount of chloride ions passing through the specimen’s section was monitored in the accelerated chloride migration test. The effective chloride diffusion coefficients () were calculated from the steady-state on the basis of Nernst-Planck’s equation. The results indicated that the initial curing conditions and the wet-dry interval of external environments have coupling influence on effective diffusion coefficient of chloride ion significantly. reflected the density and pore connectivity of concrete. The co-effects of the initial curing condition and following exposure environment should be taken into account in durability design for concrete structure located in marine environment.

关键词： durability     effective diffusion coefficient     steady-state     migration test    

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Aerosol exposure assessment during reclaimed water utilization in China and risk evaluation in case of

《环境科学与工程前沿（英文）》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1516-1

摘要：

• The Chinese population exposure habits were surveyed.

关键词： Legionella     QMRA     Reclaimed water     Aerosol     Water reuse    

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标题 作者 时间 类型 操作

Inactivation and risk control of pathogenic microorganisms in municipal sludge treatment: A review

期刊论文

Long-term exposure to air pollution and cerebrovascular disease: findings from Beijing Health Management

期刊论文

Untargeted metabolomic analysis of pregnant women exposure to perfluorooctanoic acid at different degrees

期刊论文

Ultraviolet exposure enhanced silicon direct bonding

Guanglan LIAO, Xuekun ZHANG, Xiaohui LIN, Canghai MA, Lei NIE, Tielin SHI,

期刊论文

Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational

期刊论文

Construction risks of Huaying mount tunnel and countermeasures

Haibo YAO, Feng GAO, Shigang YU, Wei DANG

期刊论文

Study of blood exposure-related mental health illness among clinical nurses

null

期刊论文

New medical risks affecting obstetrics after implementation of the two-child policy in China

null

期刊论文

Effects of hemin and thermal stress exposure on JWA expression

ZHAO Ming, CHEN Rui, LI Aiping, ZHOU Jianwei

期刊论文

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

期刊论文

Occupational risk of exposure to methicillin-resistant (MRSA) and the quality of infection hygiene in

期刊论文

Universal influenza virus vaccines: what can we learn from the human immune response following exposure

null

期刊论文

Response of bacterial communities to short-term pyrene exposure in red soil

Jingjing PENG, Hong LI, Jianqiang SU, Qiufang ZHANG, Junpeng RUI, Chao CAI

期刊论文

Influence of initial curing conditions and exposure environments on chloride migration in concrete using

Wen XUE, Weiliang JIN, Hiroshi YOKOTA,

期刊论文

Aerosol exposure assessment during reclaimed water utilization in China and risk evaluation in case of

期刊论文